Baked Bubble Up Pizza Casserole in the baking dish

Bubble Up Pizza Casserole is made with ground hot Italian sausage, pepperoni, pasta sauce, and unbaked canned biscuits. It is a quick and easy dinner recipe that the kids will love that is ready in just 30 minutes!

A convenient and easy casserole made with biscuits is great for those busy weeknights. Bubble Up Pizza Casserole is easy to make ahead of time and reheat just before your ready to eat dinner. It goes great with a serving of Caprese Salad!

A popular retro recipe and my keto option

This Bubble Up Pizza Casserole recipe was popular when my kids were young. It was a Pillsbury recipe that became popular because of the ease of making and its taste! For 1 serving, you will have 25 carbs, which, when allowing yourself a low carb diet, is not bad.

While for the most part, I stick to keto, I will incorporate a recipe like this that is not keto as a rare treat. I do make this for the rest of the family on our weekly family dinner sometimes.

sausage, pepperoni and pasta sauce in a saucepan

When I want to stick to keto, I will reserve 1 cup of the filling (see pic above) and put it in a small single-serving casserole, top with the cheese and bake it for a 6 net carb pizza casserole dinner.

What you need to make Bubble Up Pizza Casserole

Baked Bubble Up Pizza Casserole in the baking dish

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Hot Italian Sausage: We love spicy sausage on our pizza. I always buy ground hot Italian Sausage for this recipe. It adds a ton of flavor without packing too much heat.

Pepperoni Slices: I used a pork pepperoni. Cut the pepperoni slices in half or in quarters, whatever way you like. I measured the whole slices into 1/2 cup, then cut them.

Pasta or Pizza Sauce: I use a sugar-free pasta sauce. If I don’t have any homemade pasta sauce on hand, I will buy this brand. I love that it is sugar-free and much more budget-friendly than other sugar-free sauces.

Canned Biscuits: I use the flaky layers 10 count buttermilk biscuits made by Pillsbury. This particular biscuit has only 15 carbs per serving.

Cheese: I use a 3-cheese blend to mix into the pizza bake. Then I top it with the shredded mozzarella

Casserole Baking Dish: You will need a 9×13 baking dish. I have this dish that has a lid, making it easy to just cover and store in the fridge for those make-ahead days.

meat mixture with biscuits mixed in

Make this Pizza Casserole with Biscuits your way

This Bubble Up Pizza Casserole is a very versatile recipe. You can use any ingredients you would normally put on as a pizza topping. Below are just a few ideas that may suit you.

  • Use ground beef, pork, chicken, or turkey in place of the sausage. You can also sub out chicken sausage links. I love to use the buffalo chicken sausage links.
  • Saute some red and green pepper with the onion and ground meat.
  • Stir in 1/2 cup of black olives with the pepperoni slices.
  • Substitute turkey pepperoni for the pork pepperoni.
  • Sprinkle the top of the casserole with 1/2 cup shredded parmesan cheese and 1/2 cup mozzarella cheese.
  • Substitute 2 cups of cooked penne pasta for the biscuit dough.
  • Instead of mixing the pepperoni into the sauce mixture, lay it over top of the cheese on the casserole before baking.
bubble up pizza casserole with a serving removed and the serving spatula in the dish

Other Casseroles you may enjoy

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[mv_create key=”570″ type=”list” title=”Family Friendly Casseroles (for a regular diet)” thumbnail=”” layout=”hero”]
Bubble Up Pizza Casserole

Bubble Up Pizza Casserole

All the components of a pizza tossed with canned biscuit dough and baked in a casserole dish.
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Course: Main Dish
Cuisine: American
Keyword: Bubble Up Pizza Casserole, Pizza Bake, Pizza Casserole, Pizza Casserole with Biscuits
Prep Time: 10 minutes
Cook Time: 20 minutes
Total Time: 30 minutes
Servings: 8 servings
Calories: 544kcal


  • 1 pound hot Italian sausage
  • 1/2 cup sliced pepperoni
  • 1/4 cup diced onion
  • 2 cups pasta sauce
  • 1 can biscuit dough
  • 1 cup shredded pizza cheese blend
  • 1 cup shredded mozzarella cheese


  • In a large skillet, crumble and cook the hot Italian sausage over medium-high heat for 3 minutes. Stir in diced onion and cook for 5 minutes, or until sausage has browned.
  • Stir in pasta sauce and pepperoni slices and simmer for 5 minutes. Remove from heat.
  • Cut the biscuit dough into quarters and stir into the meat mixture with the pizza cheese blend.
  • Transfer to a casserole dish coated with cooking spray. Sprinkle with mozzarella cheese and bake for 20 minutes or until cheese has browned.



Calories: 544kcal | Carbohydrates: 10g | Protein: 27g | Fat: 43g | Saturated Fat: 11g | Cholesterol: 108mg | Sodium: 1417mg | Fiber: 0.6g | Sugar: 4g

About the Author: Shelby Law Ruttan

Shelby is the author/owner of Grumpy's Honeybunch. Established in 2007, she shares and preserves family recipes as well as recipes for cooking light and keto. She is an experienced, self-taught home cook who loves to share recipes with others. You can see her work on websites such as Veal Made Easy, Parade, Community Table, SoFab Food, Yummly, and FoodGawker.



  2. Mary January 16, 2021 at 7:32 pm - Reply

    I do not see a baking temperature listed. What should I use?

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Shelby Welcome! I'm Shelby, author of Grumpy's Honeybunch. I have been sharing family favorite recipes since 2007. I started the Keto Diet in October 2017 and since then I have been creating Keto ... read more

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