Preheat the oven to 350 degrees F. Spray a loaf pan with cooking spray; set aside.
Crumble the ground beef into a large bowl. Add the egg, diced onion, pickle juice, chopped pickles, salt, pepper, and bread crumbs in to the meat. Using your hands, mix together until the ingredients are just combined.
Transfer the meat mixture to the prepared loaf pan and pat the meatloaf mixture in tight.
Stir together the ketchup, water, sugar, and Worcestershire sauce. Pour the sauce mixture over the meatloaf.
Bake in preheated oven for 1 hour, or until no longer pink in the center and an instant-read thermometer inserted into the center reads at least 160 degrees F.
Store leftovers in an air-tight container in the refrigerator up to 5 days.
Notes
Make this recipe keto friendly by doing the following:
Substitute ground pork rinds for the bread crumbs
Use a brown sugar erythritol sweetener for the brown sugar.
Be sure the ketchup is sugar free.
Add ½ teaspoon basil, ½ teaspoon oregano, and ¼ teaspoon ground thyme to the meatloaf mixture